Kill Mom's Heart on Hard Mode with Lazarus. Kill Mom's Heart on Hard Mode with Azazel. Kill Mom's Heart on Hard Mode with Judas. Kill Mom's Heart on Hard Mode with Maggy. Kill Mom's Heart on Hard Mode with Isaac. Get 4 Cube of Meat items in a single run.Ĭollect 2 of these items in a single run: Roid Rage, The Viurs, Growth Hormones, Experimental Treatment, or Speed Ball.ĭonate 100 coins to the Donation Machine.ĭonate 200 coins to the Donation Machine.ĭonate 600 coins to the Donation Machine.īeat The Chest/Dark Room and a Boss Rush Room on Hard Mode as The Lost.
(You cannot die inbetween these runs, but you can restart as many times as you want)īeat The Chest/Dark Room without taking damage.Ĭollect every item and unlock every ending in the game.īeat all possible bosses in The Basement.ĭonate 150 coins to the Donation Machine.ĭonate 400 coins to the Donation Machine.ĭonate 999 coins to the Donation Machine. Kill Ultra Pride or beat The Chest with Judas.īuy 3 items from the Devil Room in one run.ĭie as Isaac to a Mulliboom in The Basement/Cellar, by your own bomb as Maggy in The Caves/Catacombs, to Mom's Foot as Judas, and to Satan's projectiles as Azazel. Unlock all items, secrets, and endings except for "The Lost" and his unlockable items. Get 4 Ball of Bandage items in a single run.Ĭollect 2 of the following items: Bob's Rotten Head, Dead Cat, Cricket's Head, Tammy's Head in one run.īeat The Basement/Cellar without taking damage.īeat The Caves/Catacombs without taking damage.īeat The Depths/Necropolis without taking damage.īeat The Womb/Utero without taking damage.ĭon't pick up any hearts for 2 floors in a row.Ĭollect Key Piece 1 and Key Piece 2 in the same run.ĭonate 900 pennies to the Donation Machine. Kill a Harbringer (Horseman) for the first time. Have 7 or more red heart containers at one time.
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